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International Clinical Trial: Physiological Biomarker-Based Neural Dosing Study: A prospective, multicenter, single-arm study evaluating the clinical utility of biomarker-based neural dosing using evoked compound action potential (ECAP)-controlled closed-loop spinal cord stimulation (SCS)

Geneva, Aug. 31 -- International Clinical Trials Registry received information related to the study (ACTRN12626001018303) titled 'Physiological Biomarker-Based Neural Dosing Study: ... Read More


International Clinical Trial: Does Catheter Ablation Improve Cognitive Function Over 12 and 24 Months as Compared with Standard Medical Therapy in Patients Aged 67 years and Older with Persistent Atrial Fibrillation (AF)?: A Randomised Clinical Trial

Geneva, Aug. 31 -- International Clinical Trials Registry received information related to the study (ACTRN12626001019392) titled 'Does Catheter Ablation Improve Cognitive Function Over 12 and 24 Month... Read More


International Clinical Trial: Gait Training in Dementia

Geneva, Aug. 31 -- International Clinical Trials Registry received information related to the study (ACTRN12626001016325) titled 'Gait Training in Dementia' on Aug. 18. Study Type: Interventional S... Read More


International Clinical Trial: Biomechanical effects of 3D-printed metamaterial foot orthoses with anti-pronatory graded stiffness on lower limb kinematics and kinetics in healthy adults: A within subjects immediate effects cross over study

Geneva, Aug. 31 -- International Clinical Trials Registry received information related to the study (ACTRN12626001015336) titled 'Biomechanical effects of 3D-printed metamaterial foot orthoses with an... Read More


Clinical Trial: Multicenter Prospective Observational Study of the Safety and Efficacy of ICI Rechallenge After Severe ICI-Induced Liver Injury (Japan)

Tokyo, Aug. 21 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000062598) titled 'Multicenter Prospective Observational Study of Immune Checkpoint Inhibitor ... Read More


Singapore Clinical Trial: An Open-label, Randomized, Controlled Phase 3 Study of Disitamab Vedotin in Combination with Pembrolizumab Versus Chemotherapy in Subjects with Previously Untreated Locally Advanced or Metastatic Urothelial Carcinoma that Expresses HER2 (IHC 1+ and Greater)

Singapore, Aug. 17 -- The Health Sciences Authority received information related to the study titled 'An Open-label, Randomized, Controlled Phase 3 Study of Disitamab Vedotin in Combination with Pembr... Read More


Singapore Clinical Trial: A Randomized, Open-label, Phase 3 Study of Rina-S ± Bevacizumab Versus Investigator's Choice of Platinum-Based Chemotherapy ± Bevacizumab as 2L Treatment in Participants With Recurrent Platinum-Sensitive Ovarian Cancer

Singapore, Aug. 17 -- The Health Sciences Authority received information related to the study titled 'A Randomized, Open-label, Phase 3 Study of Rina-S ± Bevacizumab Versus Investigator's Choice of Pl... Read More


Singapore Clinical Trial: ROSETTA Lung-201: A Randomized, Multicenter, Open-label Phase 3 Study of Pumitamig Monotherapy Compared to Durvalumab in Participants with Unresectable Stage III NSCLC Without Progression After Platinum-based Concurrent Chemoradiation Therapy.

Singapore, Aug. 17 -- The Health Sciences Authority received information related to the study titled 'ROSETTA Lung-201: A Randomized, Multicenter, Open-label Phase 3 Study of Pumitamig Monotherapy Com... Read More


Singapore Clinical Trial: A Phase 2, Randomized, Open-Label Study of VVD-133214 in Combination with Pembrolizumab compared with Pembrolizumab monotherapy in participants with advanced colorectal adenocarcinoma (CRC) harboring microsatellite instability (MSI) and/or deficient mismatch repair (DMMR)

Singapore, Aug. 17 -- The Health Sciences Authority received information related to the study titled 'A Phase 2, Randomized, Open-Label Study of VVD-133214 in Combination with Pembrolizumab compared w... Read More


Singapore Clinical Trial: A Phase 3, Randomized, Double-blind, Placebo-controlled Study of Investigator Choice of Chemotherapy (modified FOLFIRINOX or Gemcitabine plus Nab-paclitaxel) with or without Zoldonrasib (RMC 9805) as First-line Treatment in Patients with Metastatic KRAS G12D-mutated Pancreatic Adenocarcinoma (RASolute 305)

Singapore, Aug. 17 -- The Health Sciences Authority received information related to the study titled 'A Phase 3, Randomized, Double-blind, Placebo-controlled Study of Investigator Choice of Chemothera... Read More